The Paired Availability Design for Historical Controls
نویسندگان
چکیده
منابع مشابه
The Paired Availability Design for Historical Controls
BACKGROUND Although a randomized trial represents the most rigorous method of evaluating a medical intervention, some interventions would be extremely difficult to evaluate using this study design. One alternative, an observational cohort study, can give biased results if it is not possible to adjust for all relevant risk factors. METHODS A recently developed and less well-known alternative i...
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Clarifying the role of principal stratification in the paired availability design.
The paired availability design for historical controls postulated four classes corresponding to the treatment (old or new) a participant would receive if arrival occurred during either of two time periods associated with different availabilities of treatment. These classes were later extended to other settings and called principal strata. Judea Pearl asks if principal stratification is a goal o...
متن کاملUse of historical controls for animal experiments.
Statistical methods for the use of historical control data in testing for a trend in proportions in carcinogenicity rodent bioassays are reviewed. Asymptotic properties of the Hoel-Yanagawa exact conditional tests are developed and compared with the Tarone test. It is indicated that the Hoel-Yanagawa test is more powerful than the Tarone test. These tests depend on the beta-binomial parameters ...
متن کاملNotes on the use of historical controls.
The principles and methods of incorporating historical controls in four cases (C1, stable control; C2, rare occurrence of responses; C3, small group size; C4, historical control as a reference) are discussed. Two points are emphasized: one is that the historical control should be regarded as a given condition and the other is that the historical control should be used conservatively. Incorporat...
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ژورنال
عنوان ژورنال: BMC Medical Research Methodology
سال: 2001
ISSN: 1471-2288
DOI: 10.1186/1471-2288-1-9